Is a semen analysis the same as DNA fragmentation testing?

Is a semen analysis the same as DNA fragmentation testing?

Did you know that almost a third of fertility problems are related to male factor? Did you also know that anywhere between 30-50 percent of male infertility cases are due to sperm defects?

As the examination of the male is relatively non-invasive, this will often be the first test performed when investigating the cause of infertility.

At Fertility First, our andrologists assess male fertility through a semen analysis to measure the key parameters of semen known to impact fertility. Our scientists will also perform DNA fragmentation testing, which is designed to assess the genetic integrity of your sperm.

A basic semen analysis consists of analysing the number of sperm you have as well as the motility and the morphology. It is a test all fertility clinics offer their male patients who are looking at undergoing fertility treatment.

A DNA fragmentation test is an assay performed through a technique known as HALO, which examines the DNA inside the sperm’s chromosomes and helps to provide clinical diagnosis and the management of male infertility.

Assessing DNA damage in your sperm is important when wanting to start a family. Research has previously shown that high levels of DNA fragmentation can have adverse effects in fertilisation, embryo quality, pregnancy rates and increase the likelihood of miscarriages four-fold.

Fertility First has recognised the importance of sperm health and genetic integrity when it comes to fertility and healthy pregnancies and have been performing tests to analyse sperm DNA damage in patients for over 15 years.

So, what happens if you receive an abnormal result?

What happens if you have abnormal sperm?

An abnormal test result does not mean that you cannot have children. This simply will assist our team to determine the best form of fertility treatment for you. DNA fragmentation is often linked to external factors and lifestyle:

  • Smoking
  • Recreational drug use
  • Alcohol
  • Obesity
  • Long periods between ejaculation
  • Stress
  • Diet
  • Advanced age
  • Environmental pollutants (air pollution, exposure to chemicals, certain work environments/occupations such as spray painting)

Our studies have shown that in more than 75 percent of patients who return a high DNA fragmentation result, those who make changes to their lifestyle and take the recommended dietary supplements suggested by their fertility specialist will see an improvement in their sperm quality within 2 months.

For more information or to make an appointment contact the clinic for more details on (02) 9586 3311.

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FAQs about improving natural fertility

Will stress affect my ability to get pregnant?

Yes, chronic stress can impact fertility by disrupting hormonal balance and ovulation patterns. Managing stress through relaxation techniques, regular exercise, adequate sleep, and mindfulness practices may help optimise your chances of conception. Consider speaking with a counsellor if stress feels overwhelming.

How does my partner's health affect our fertility?

Sperm health accounts for about 40% of conception challenges. Your partner can improve sperm health by maintaining a healthy weight, avoiding excessive heat exposure (hot tubs, saunas, tight clothing), limiting alcohol, quitting smoking, managing stress, and taking a multivitamin with antioxidants. Sperm takes about 3 months to develop, so lifestyle changes need time to show results.

When during my cycle am I most fertile?

Your fertile window typically spans 5-6 days, ending on ovulation day. For a regular 28-day cycle, this usually falls between days 10-15, with peak fertility 1-2 days before ovulation. Track your cycle using ovulation predictor kits, basal body temperature, or cervical mucus changes to identify your unique pattern. Having intercourse every 1-2 days during this window optimises your chances.