Scientists have identified a specific protein that keeps sperm swimming in a straight line. Called “VSP”, the protein is responsible for controlling the influx of calcium ions to the tail or flagellum of the sperm which helps the sperm swim towards to egg.
Sperm motility is an important factor that is required for fertilisation, but without motility, sperm can’t make its way up to the fallopian tube and to the egg. When the sperm is close to its destination, it will become turbo-charged (also known as capacitation) and will ultimately race towards the egg.
The sudden enhanced motility of the sperm is caused by an influx of calcium ions to the sperm’s tail, which is controlled by VSP. Without VSP, the sperm will lose its ability to effectively race towards the egg.
When observed closely, the researchers noticed that sperm deficient in VSP were in fact swimming around in circles during that final leg of their journey, making it harder for them to reach the egg.
A Beacon of Hope for Fertility Treatments
This discovery of VSP’s role in sperm motility is a significant breakthrough. By understanding the mechanisms that regulate sperm movement, researchers can now explore potential avenues for developing novel fertility treatments. These treatments could target VSP or its associated pathways to improve sperm motility in men experiencing infertility due to motility issues.
The hope is that by optimizing sperm motility, these future treatments will lead to increased fertilisation rates, offering new hope for couples on their path to parenthood.
While further research is needed to translate this discovery into clinical applications, it represents a significant step forward in the field of reproductive medicine. The identification of VSP offers a promising target for future therapies, potentially aiding countless couples increse their chances of fertility treatment success.
Interested in learning more about new fertility research? Stay up-to-date with current research, news and important information with our fertility blog.
